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AOPEN DE945-HG DRIVER
In addition, we observed that, for most of the adverse effects evaluated, prevalence increased as the daily dose of ICS was increased, especially for loss of voice Aopen DE945-HG.
Table 3 Frequency of local adverse effects in the Aopen DE945-HG studied, by use of medium- or high-dose inhaled corticosteroids. Table 4 Open in a separate window Discussion In the present study, patient perception of adverse effects in the oral cavity and pharynx was found to be high among the subjects with moderate or severe asthma being evaluated in clinical practice. More than half of the patients The most prevalent symptoms were dry throat, need for throat clearing, and sensation of thirst, the last being the most commonly reported adverse effect, affecting approximately one quarter of the subjects daily.
The high frequency of local adverse effects induced by ICSs found in the present study is in agreement with the findings of various authors who used structured questionnaires.
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The frequency of adverse effects in Aopen DE945-HG oral cavity and pharynx varies widely. The frequency of these local effects can vary depending on the ICS dose and potency, as well as on the type of inhaler used. Aopen DE945-HG local adverse effect is defined as laryngitis caused by ICSs, which act by inducing a form of chemical laryngopharyngitis, mimicking the clinical profile of laryngopharyngeal reflux. This local symptom can correspond to a manifestation of oral candidiasis or be caused by throat irritation. These factors include ICS formulation, type of drug delivery system, and patient adherence to the instructions for use.
According to one group of authors, high doses of ICS are associated with a higher intensity and frequency of patient-perceived adverse events.
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The good relationship between the health care team and the patient makes it possible for the asthma patients in our study to discuss their symptoms and their concerns regarding the pharmacological treatment more Aopen DE945-HG, and this favors spontaneous reporting of adverse effects of medications. According to one group of authors, open and honest communication with patients, taking their concerns seriously, can reduce the impact caused by adverse reactions to medications. A previous study has demonstrated that asthma patients prefer not to discuss their concerns regarding Aopen DE945-HG use with their physicians.
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A study conducted in Canada showed that, although some recommendations for the management of symptoms in the oral cavity and pharynx made by family physicians are logical, Aopen DE945-HG can be insufficient in some situations. Although the practice of oral hygiene after ICS use is an important measure to remove ICSs from the oral cavity, this measure is ineffective in cleaning the larynx. The study design allowed us to Aopen DE945-HG the use of systemic corticosteroids in the three months preceding the study; however, we could not control their use beyond this point. In addition, it was not possible to control the use of nasal corticosteroids, the use of which was identified in more than half of the patients evaluated.
Nasal corticosteroids can penetrate the pharynx and larynx, and, consequently, they have the potential to cause symptoms in the oral cavity and pharynx.
In conclusion, patient perception of local adverse effects associated with the use of ICSs, especially pharyngeal symptoms, including dry mouth and need for throat clearing, is high among the asthma patients followed in the ProAR Department of Pharmaceutical Care. This high frequency of local symptoms might be associated with the use of medium and Aopen DE945-HG doses of Aopen DE945-HG, as well as with long-term exposure to ICSs.
Assessment of asthma patient perception of local adverse effects of ICSs could provide a greater understanding of the extent and severity of these effects and could aid in determining the risk-benefit ratio of the use of ICSs in clinical practice. Although ICSs are highly effective in the treatment of asthma, their rational use, on the basis of a step-down therapeutic approach, must be ensured in order to reach the lowest maintenance dose consistent with the Aopen DE945-HG level of disease control.
Footnotes Financial support: References 1.
Global Initiative for Asthma. Available from: J Bras Pneumol.
Buhl R. Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. Adverse effects of inhaled corticosteroids. Am J Med. The local Aopen DE945-HG effects of inhaled corticosteroids: A self-rating scale for patient-perceived side effects of inhaled corticosteroids. Respir Res.
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