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File Name: api_generic_42161.zip
File Size: 19.9 MB
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Of note is the evidence that risperidone has been shown to be effective in maintenance treatment of schizophrenia, equivalent to haloperidol in one study Marder et al.

Economic evidence and resource utilization As noted above, the economic burden of schizophrenia is large for many reasons, only partly because of the acquisition costs of brand name medications. No formal economic analysis has been published for paliperidone. However, the costs of paliperidone and risperidone are likely to be substantially different when risperidone is no longer governed by patent protection in June However, potential savings in hospital costs could make up this difference if paliperidone leads to a quicker response or API Generic US9 K9 social functioning.


Significant separation from placebo is seen as early as day 4 in the three efficacy trials, although a similar analysis of data was not done for olanzapine. Moreover, the long-term relapse prevention trial in which titration of medication was allowable resulted in mean doses of paliperidone greater than 6 mg.

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While paliperidone did improve functioning on the PSP, similar results are reported for olanzapine and risperidone in the three API Generic US9 K9 trials and CATIE trial, respectively. To repeat, a direct comparison with other antipsychotics is needed before definitive recommendations about these potential benefits can be made.


It can, however, be said with confidence that paliperidone is likely to cost considerably more than generic risperidone. A trial of economic outcomes for patients treated with paliperidone is currently recruiting patients, as listed at www.

Paliperidone: the evidence of its therapeutic value in schizophrenia

The once-a-day dosing is helpful. Given its lack of hepatic metabolism, it may be particularly useful in patients with liver disease. No trials have been performed in other disease classifications, in contrast to risperidone, which has regulatory approval to treat bipolar mania and irritability associated with autistic disorder in children and adolescents. Dosage, administration, and formulations Paliperidone Invega is API Generic US9 K9 as 3, 6, and 9 mg tablets.

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At present, only the extended-release oral formulation is available. The recommended starting dose is 6 mg once daily, administered in the morning. Paliperidone must be swallowed whole and should not be chewed, divided, or crushed. The tablet shell, along API Generic US9 K9 insoluble core components, is eliminated from the body in the stool.

Place in therapy Schizophrenia is a severe, chronic, and disabling illness. Although many different antipsychotic drugs are available, their overall effectiveness is less than optimal.

Some patients have no response to available drugs. Other patients have residual symptoms despite adequate drug treatment. Many patients respond to treatment, but have noxious or intolerable side effects that often contribute to poor medication adherence. For these reasons, new drug API Generic US9 K9 are always needed, and the purpose of this review was to evaluate the place of paliperidone in the treatment of schizophrenia.


Paliperidone has a significantly different hepatic enzyme and metabolic profile compared with risperidone and several other atypical antipsychotic drugs, and is more effective than placebo API Generic US9 K9 treating schizophrenia. It appears to be equivalent in efficacy to a relatively low dose of olanzapine. It remains to be seen whether it should be used in place of risperidone; the only clear advantage of paliperidone is the minimal hepatic metabolism, which may be important with respect to drug interaction potential. Although the extended-release formulation allows for once-daily administration, risperidone is also approved for this dosage frequency.

A claim that paliperidone can be initiated at a therapeutic dose and has unique benefits API Generic US9 K9 improving social functioning is only minimally supported by the limited evidence currently available Kramer et al.

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A controlled clinical trial directly API Generic US9 K9 paliperidone and risperidone is highly desirable in order to contrast and compare these two agents. Until such a trial is performed, despite its effectiveness over placebo and theoretical advantages, it is difficult to justify first-line paliperidone use over risperidone, and it will become even harder to API Generic US9 K9 when risperidone becomes available as a less expensive generic medication. Acknowledgments Leslie Citrome, MD, MPH, is a consultant for, has received honoraria from, or has conducted clinical research supported by the following: Risperidone and breast-feeding. API Generic US9 K/9 drivers were collected from official websites of manufacturers and other trusted sources. Official driver packages will help you to restore.

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